R12可以替代R134a,但是R134a不能替代R12。制冷剂有R12、R22、R134a、R152a、R600a、H-01、rh、H、R404、R401、R152a和R22混合制冷剂。常用的制冷剂有R12、R22、R134a、R152a、R600a。一般都可以用R12、R22代换。R152a、H-01、rh、H、R404、R152a和R22混合制冷剂,可以用R12代换。R404、R152a和R22混合制冷剂，可以用R22代换。